- 2019 -

Novel mediators of aneurysm progression in bicuspid aortic valve disease.

Authors: Tobin SW, Alibhai FJ, Lee MM, Yeganeh A, Wu J, Li SH, Guo J, Tsang K, Tumiati L, Rocha R, Butany J, Yau TM, Ouzounian M, David TE, Weisel RD, Li R-K.
Reference: J Mol Cell Cardiol. 2019 Jul;132:71-83. doi: 10.1016/j.yjmcc.2019.04.022. Epub 2019 Apr 29

Knockout of Canopy 2 activates p16INK4a pathway to impair cardiac repair.

Authors: Yin W, Guo J, Zhang C, Alibhai FJ, Li SH, Billia P, Wu J, Yau TM, Weisel RD, Li R-K.
Reference: J Mol Cell Cardiol. 2019 Jul;132:36-48. doi: 10.1016/j.yjmcc.2019.04.018. Epub 2019 Apr 29.

Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias.

Authors: Romagnuolo R, Masoudpour H, Porta-Sánchez A, Qiang B, Barry J, Laskary A, Qi X, Massé S, Magtibay K, Kawajiri H, Wu J, Valdman Sadikov T, Rothberg J, Panchalingam KM, Titus E, Li R-K, Zandstra PW, Wright GA, Nanthakumar K, Ghugre NR, Keller G, Laflamme MA
Reference: Stem Cell Reports. 2019 May 14;12(5):967-981. doi: 10.1016/j.stemcr.2019.04.005. Epub 2019 May 2

Effect of neuron-derived neurotrophic factor on rejuvenation of human adipose-derived stem cells for cardiac repair after myocardial infarction.

Authors: Yang K, Song HF, He S, Yin WJ, Fan XM, Ru F, Gong H, Zhai XY, Zhang J, Peng ZX, Xi GX, Xie J, Li R-K.
Reference: J Cell Mol Med. 2019 Sep;23(9):5981-5993. doi: 10.1111/jcmm.14456. Epub 2019 Jul 9

Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation.

Authors: Li J, Li SH, Dong J, Alibhai FJ, Zhang C, Shao ZB, Song HF, He S, Yin WJ, Wu J, Weisel RD, Liu SM, Li R-K.
Reference: Aging Cell. 2019 Dec;18(6):e13026. doi: 10.1111/acel.13026. Epub 2019 Aug 5.

CD34 stem cells: promising roles in cardiac repair and regeneration

Authors: Marvasti TB, Alibhai FJ, Weisel RD. Li R-K
Reference: Can J Cardiol. 2019 Oct;35(10):1311-1321. doi: 10.1016/j.cjca.2019.05.037. Epub 2019 Jun 11. Review

Commentary: Circulating factors released after myocardial infarction: Beneficial or detrimental?

Author(s): Alibhai FJ, Li R-K.
Reference: J Thorac Cardiovasc Surg. 2018 Nov 8. doi: 10.1016/j.jtcvs.2018.10.128. [Epub ahead of print]

Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2

Author(s): Shao Z, Wu J, Du G, Song H, Li S-H, He S, Li J, Wu J, Weisel RD, Yuan H, Li R-K.
Reference: J Cell Mol Med. 2018 Dec;22(12):6176-6189. doi: 10.1111/jcmm.13905. Epub 2018 Sep 25.

Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases

Author(s): Zhang DY, Zhang CF, Fu BC, Sun L, Wang XQ, Chen W, Liu W, Liu KY, Du GQ, Ma CY, Jiang SL, Li R-K, Tian H.
Reference: J Cell Mol Med. 2018 Nov;22(11):5504-5517. doi: 10.1111/jcmm.13821. Epub 2018 Aug 9.

Emerging roles of extracellular vesicles in cardiac repair and rejuvenation

Author(s): Alibhai FJ, Tobin SW, Yeganeh A, Weisel RD, Li R-K.
Reference: Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H733-H744. doi: 10.1152/ajpheart.00100.2018. Epub 2018 Jun 27.

Polypyrrole-Chitosan conductive biomaterial synchronizes cardiomyocytes contraction and improves myocardial electrical impulse propagation

Author(s): Cui Z, Ni NC, Wu J, Du GQ, He S, Yau TM, Weisel RD, Sung HW, Li R-K.
Reference: Theranostics. 2018 Apr 9;8(10):2752-2764. doi: 10.7150/thno.22599. eCollection 2018.

Young bone marrow Sca-1-cells rejuvenate the aged heart by promoting epithelial-to-mesenchymal transition

Author(s): Li J, Li S-H, Wu J, Weisel RD, Yao A, Stanford WL, Liu S-M, Li R-K.
Reference: Theranostics. 2018 Feb 12;8(7):1766-1781. doi: 10.7150/thno.22788. eCollection 2018.

Preservation of conductive propagation after surgical repair of cardiac defects with a bio-engineered conductive patch

Author(s): He S, Song H, Wu J, Li S-H, Weisel RD, Sung HW, Li J, Li R-K.
Reference: J Heart Lung Transplant. 2018 Jul;37(7):912-924. doi: 10.1016/j.healun.2017.12.011. Epub 2017 Dec 20.

Bioactive coating of decellularized vascular grafts with a temperature-sensitive VEGF-conjugated hydrogel accelerates autologous endothelialization in vivo

Author(s): Iijima M, Aubin H, Steinbrink M, Schiffer F, Assmann A, Weisel RD, Matsui Y, Li R-K, Lichtenberg A, Akhyari P.
Reference: J Tissue Eng Regen Med. 2018 Jan;12(1):e513-e522. doi: 10.1002/term.2321. Epub 2017 May 23.

Aged human multipotent mesenchymal stroma cells can be rejuvenated by neuron-derived neurotrophic factor and improve heart function after injury

Author(s): Song H, He S, Li S-H, Yin W, Wu J, Guo J, Shao Z, Zhai X, Gong H, Lu L, Wei F, Weisel RD, Xie J, Li R-K.
Reference: JACC Basic Transl Sci. 2017 Nov 29;2(6):702-716. doi: 10.1016/j.jacbts.2017.07.014. eCollection 2017 Dec.

A circular RNA binds and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair

Author(s): Zeng Y, Du WW, Wu Y, Yang Z, Awan FM, Li X, Yang W, Zhang C, Yang Q, Yee A, Chen Y, Yang F, Sun H, Huang R, Yee AJ, Li R-K, Wu Z, Backx PH, Yang BY.
Reference: Theranostics. 2017 Aug 29;7(16):3842-3855. doi: 10.7150/thno.19764. eCollection 2017.

Flexible shape-memory scaffold for minimally invasive delivery of functional tissues

Author(s): Montgomery, M., Ahadian, S., Davenport-Huyer, L., Rito, M. L., Civitarese, R. A., Vanderlaan, R., Wu, J., Reis, L. A., Momen, A., Akbari, S., Pahnke, A., Li, R-K., Caldarone, C. A.,  Radisic, M.
Reference: Nat Mater. 2017 Oct;16(10):1038-1046. doi: 10.1038/nmat4956. Epub 2017 Aug 14.

Suppression of miR-34a expression in the myocardium protects against ischemia reperfusion injury through silent information regulator 1 protective pathway

Author(s): Fu BC, Lang JL, Zhang DY, Sun L, Chen W, Liu W, Liu KY, Ma CY, Jiang SL, Li R-K, Tian H.
Reference: Stem Cells Dev. 2017 Sep 1;26(17):1270-1282. doi: 10.1089/scd.2017.0062. Epub 2017 Jul 20.

Dual roles for bone marrow-derived Sca-1 cells in cardiac function

Author(s): Tobin S, Li S-H, Li J, Wu J, Yeganeh A., Yu P, Weisel RD, Li R-K.
Reference: FASEB J. 2017 Jul;31(7):2905-2915. doi: 10.1096/fj.201601363RR. Epub 2017 Mar 23.

Nr2e1 Down regulation is involved in excess retinoic acid-induced development abnormality in the mouse brain

Author(s): Yu J, Guo Q, Mu JB, Zhang T, Li R-K, Xie J.
Reference: Biomed Environ Sci. 2017 Mar;30(3):185-193. doi: 10.3967/bes2017.026.

Young Bone-Marrow Sca-1+ Stem Cells Rejuvenate the Aged Heart and Improve Function after Injury through PDGFRβ-Akt pathway

Author(s): Li S-H, Sun L, Yang L, Li J, Shao Z-B, Du G, Wu J, Weisel RD, Li R-K.
Reference: Sci Rep. 2017 Jan 31;7:41756. doi: 10.1038/srep41756.

Targeted myocardial delivery of GDF11 gene rejuvenates the aged mouse heart and enhances myocardial regeneration after ischemia-reperfusion injury

Author(s): Du G-Q, Wu J, Shao Z-B, Li S-H, Wu J, Ni NC, Weisel RD, Tian J-W, Li R-K.
Reference: Basic Res Cardiol. 2017 Jan;112(1):7. doi: 10.1007/s00395-016-0593-y. Epub 2016 Dec 21.

Ultrasound-targeted microbubble destruction in gene therapy: A new tool to cure human diseases

Author(s): Wu J, Li R-K.
Reference: Genes Dis. 2016 Aug 20;4(2):64-74. doi: 10.1016/j.gendis.2016.08.001. eCollection 2017 Jun.

Rodness, J., Mihic, A., Miyagi, Y., Wu, J., Weisel, R. D., Li, R-K. (2016). VEGF-loaded microsphere patch for local protein delivery to the ischemic heart. Acta Biomaterialia, 1(45), 169-181.

Zhai, X. Y., Yan, P., Zhang, J., Song, H. F., Yin, W. J., Gong, H., Li, H., Wu, J., Xie, J., Li, R-K. (2016). Knockdown of SIRT6 enables human bone marrow mesenchymal stem cell senescence. Rejuvenation Research, 2015(5), 373-384.

Iijima, M., Aubin, H., Steinbrink, M., Schiffer, F., Assmann, A., Weisel, R. D., Matsui, Y., Li, R-K., Lichtenberg, A., Akhyari, P. (2016). Bio-active coating of decellularized vascular grafts with a temperature-sensitive VEGF-conjugated hydrogel accelerates autologous endothelialization in vivo. Journal of Tissue Engineering and Regenerative Medicine, 12(1), 513-522.

Hatta, K., Zhang, Y., Wu, J., Sun, Z., Weisel, R. D., Li, R-K. (2016). Uterine derived CD11b cells significantly increase vasculogenesis and promote myocardial healing in cardiomyopathy. Cell Transplantation, 25(9), 1665-1674.

Noiseux, N., Mansour, S., Weisel, R. D., Stevens, L., Der Sarkissian, S., Tsang, K., Crean, A., Laros,e E. , Li, S., Wintersperger, B., Vu, M., Prieto, I., Li, R-K., Roy, D. C., Yau, T. M. (2016). The IMPACT-CABG trial: A multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic cardiomyopathy. The Journal of Thoracic and Cardiovascular Surgery, 6(152), 1582-1588.

Huang, X. P., Ludke, A., Dhingra, S., Guo, J., Sun, Z., Zhang, L., Weisel, R. D., Li, R-K. (2016). Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart. The FASEB Journal, 30(9), 3069-3082.

Wu, J., Song, H. F., Li, S-H., Guo, J., Tsang, K., Tumiati, L., Butany, J., Yau, T. M., Ouzounian, M., Fu, S., Tirone, E. D., Weisel, R. D., Li, R-K. (2016). Progressive Aortic Dilation Is Regulated by miR-17-Associated miRNAs. Journal of the American College of Cardiology, 67(25), 2965-2977.

Yan, P., Gong, H., Zhai, X., Feng, Y., Wu, J., He, S., Guo, J., Wang, X., Guo, R., Xie, J., Li, R-K. (2016). Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. American Journal of Pathology, 186(4), 1015-1024.

Cui, Z., Yang, B., Li, R-K. (2016). Application of Biomaterials in Cardiac Repair and Regeneration. Pharmaceutical Engineering - Review, 2(1), 141-148.

Dadson, K., Kovacevic, V., Rengasamy, P., Kim, G. H., Boo, S., Li, R-K., George, I., Schulze, P. C., Hinz, B., Sweeney, G. (2016). Cellular, structural and functional cardiac remodelling following pressure overload and unloading. International Journal of Cardiology, 216, 32-42.

Nazari, M., Ni, N. C., Lüdke, A., Li, S-H., Guo, J., Weisel, R. D., Li, R-K. (2016). Mast cells promote proliferation and migration and inhibit differentiation of mesenchymal stem cells through PDGF. Journal of Molecular and Cellular Cardiology, 94, 32-42.

Zhang, Y. N., Xie, B. D., Sun, L., Chen, W., Jiang, S. L., Liu, W., Bian, F., Tian, H., Li, R-K. (2016). Phenotypic switching of vascular smooth muscle cells in the ‘normal region’ of aorta from atherosclerosis patients is regulated by miR-145. Journal of Cellular and Molecular Medicine, 20(6), 1049-1061.

Ni, N. C., Jin, C. S., Cui, L., Shao, Z., Wu, J., Li, S-H., Weisel, R. D., Zheng, G., Li, R-K. (2016). Non-invasive Macrophage Tracking Using Novel Porphysome Nanoparticles in the Post-myocardial Infarction Murine Heart. Molecular Imaging Biology, 1 8(4), 557-568.

Shao, Z., Nazari, M., Guo, L., Li, S-H., Sun, J., Liu, S. M., Yuan, H. P., Weisel, R. D., Li, R-K. (2015). The cardiac repair benefits of inflammation do not persist: Evidence from mast cell implantation. Journal of Cellular and Molecular Medicine, 20(10), 1-12.

Leung, B. M., Miyagi, Y., Li, R-K., Sefton, M. V. (2015). Fate of modular cardiac tissue constructs in a syngeneic rat model. Journal of Tissue Engineering and Regenerative Medicine, 9(11), 1247-58.

Guo, J., Mihic, A., Wu, J., Zhang, Y., Singh, K., Dhingra, S., Weisel, R. D., Li, R-K. (2015). Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy. European Heart Journal, 36(37), 2530-2540.

Cheng, H., Li, H., Bu, Z., Zhang, Q., Bai, B., Zhao, H., Li, R-K., Zhang, T., Xie, J. (2015). Functional variant in methionine synthase reductase intron-1 is associated with pleiotropic congenital malformations. Molecular Cell Biochemistry, 407(1-2), 51-56.

Mihic, A., Cui, Z., Wu, J., Miyagi, Y., Li, S-H., Lu, S., Sung, H. W., Weisel, R. D., Li, R-K. (2015). A Conductive Polymer Hydrogel Supports Cell Electrical Signaling and Improves Cardiac Function After Implantation into Myocardial Infarction. Circulation, 132(8), 772-84.

Ludke, A., Wu, J., Nazari, M., Hatta, K., Zhengbo, S., Li, S-H., Huifang, S., Nathan, N. C., Weisel, R. D., Li, R-K. (2015). Uterine-derived progenitor cells are immunoprivileged and effectively improve cardiac regeneration when used for cell therapy. Journal of Molecular and Cellular Cardiology, 84, 116-28.

Jahng, J. W., Turdi, S., Kovacevic, V., Dadson, K., Li, R-K., Sweeney, G. (2015). Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency. Endocrinology, 156(7), 2667-2677.

Sun, Z., Wu, J., Li, S-H., Zhang, Y., Xaymardan, M., Wen, X. Y., Weisel, R. D., Keating, A., Li, R-K. (2015). Uterine-derived stem cells reconstitute the bone marrow of irradiated mice. Stem Cells Dev, 24(8), 938-47.

Reis, L. A., Chiu, L. L., Wu, J., Feric, N., Laschinger, C., Momen, A., Li, R-K., Radisic, M. (2015). Hydrogels with integrin-binding angiopoietin-1-derived peptide, QHREDGS, for treatment of acute myocardial infarction. Circulation: Heart Failure, 8(2), 333-341.

Guo, J., Zhang, Y., Mihic, A., Li, S-H., Sun, Z., Shao, Z., Wu, J., Weisel, R. D., Li, R-K. (2015). A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation. Cardiovascular Research, 105(3), 383-393.

Noyan, H., El-Mounayri, O., Isserlin, R., Arab, S., Momen, A., Cheng, H. S., Wu, J., Afroze, T., Li, R-K., Fish, J. E., Bader, G. D., Husain, M. (2015). Cardioprotective Signature of Short-Term Caloric Restriction. PLoS One, 10(6), e0130658.

Dhingra, S., Wu, J., Li, S-H., Guo, J., Huang, X. P., Mihic, A., Hu, J., Weisel, R. D., Li, R-K. (2015). Modulation of allo-immune responses by interleukin-10 prevents rejection of implanted allogeneic smooth muscle cells and restores post-infarction ventricular function. Cell Transplant, 24(6), 1013-1029.

Hatta, K., Guo, J., Ludke, A., Dhingra, S., Singh, K., Huang, M. L., Weisel, R. D., Li, R-K. (2014). Expression of CNPY2 in mouse tissues: Quantification and localization. PLoS One, 9(11), e111370.

Wang, X. Q., Shao, Y., Ma, C. Y., Chen, W., Sun, L., Liu, W., Zhang, D. Y., Fu, B. C., Liu, K. Y., Jia, Z. B., Xie, B. D., Jiang, S. L., Li, R-K., Tian, H. (2014). Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress. Journal of Cellular and Molecular Medicine, 18(11), 2298-2310.

Shahzad, U., Li, G., Zhang, Y., Li, R-K., Rao, V., Yau, T. (2014). Transmyocardial Revascularization Enhances Bone Marrow Stem Cell Engraftment in Infarcted Hearts Through SCF-C-kit and SDF-1-CXCR4 Signaling Axes. Stem Cell Reviews and Reports, 11(2), 332-346.

Witty, A., Mihic, A., Tam, R., Fisher, S., Mikryukov, A., Shoichet, M., Li, R-K., Kattman, S. (2014). The generation of the epicardial lineage from human pluripotent stem cells. Nature Biotechnology, 32(10), 1026-1035.

Sun, X., Momen, A., Wu, J., Noyan, H., Li, R-K., Von Harsdorf, R., Husain, M. (2014). p27 protein protects metabolically stressed cardiomyocytes from apoptosis by promoting autophagy. J Biol Chem, 289(24), 16924-16935.

Wang, H. B., Yang, L., Wu, J., Sun, L., Wu, J., Tian, H., Weisel, R. D., Li, R-K. (2014). Reduced ischemic injury after stroke in mice by angiogenic gene delivery via ultrasound-targeted microbubble destruction. J Neuropathol Exp Neurol, 73(6), 548-558.

Zhang, L., Chen, X., Sharma, P., Moon, M., Sheftel, A. D., Dawood, F., Nghiem, M. P., Wu, J., Li, R-K., Gramolini, A. O., Sorensen, P. H., Penninger, J. M., Brumell, J. H., Liu, P. P. (2012). HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nature Communications, 5, 3430.

Mihic, A., Li, J., Miyagi, Y., Gagliardi, M., Li, S-H., Zu, J., Weisel, R. D., Keller, G., Li, R-K. (2014). The effect of cyclic stretch of maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes. Biomaterials, 35(9), 2798-2808.

Yan, P., Chen, K. J., Wu, J., Sun, L., Sung, H. W., Weisel, R. D., Xie, J., Li, R-K. (2014). The use of MMP2 antibody-conjugated cationic microbubble to target the ischemic myocardium, enhance Timp3 gene transfection and improve cardiac function. Biomaterials, 35(3), 1063-1073.

Wang, Y. S., Li, S-H., Guo, J., Mihic, A., Wu, J., Sun, L., Davis, K., Weisel, R. D., Li, R-K. (2014). Role of miR-145 in cardiac myofibroblast differentiation. Journal of Molecular and Cellular Cardiology, 66, 94-105.

Li, R-K., Guo, J. (2014). Single nucleotide variances can account for loss of microRNA function - The emerging calk between genetics and epigenetics. Journal of the American College of Cardiology, 63(3), 278-280.

Li, S-H., Guo, J., Wu, J., Sun, Z., Han, M., Shan, S. W., Deng, Z., Yang, B. B., Weisel, R. D., Li, R-K. (2013). miR-17 targets tissue inhibitor of metalloproteinase 1 and 2 to modulate cardiac matrix remodeling. FASEB J, 27(10), 4254-4265.

Park, M., Wu, D., Park, T., Choi, C. S., Li, R-K., Cheng, K. K., Xu, A., Sweeney, G. (2013). APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction. American Journal of Physiology - Endocrinology and Metabolism, 305(7), E795-804.

Dhingra, S., Li, P., Huang, X. P., Guo, J., Wu, J., Mihic, A., Li, S-H., Zang, W. F., Shen, D., Weisel, R. D., Singal, P. K., Li, R-K. (2013). Preserving prostaglandin E2 level prevents rejection of implanted allogeneic mesenchymal stem cells and restores postinfarction ventricular function. Circulation, 128(11 Suppl 1), S69-78.

Li, P., Li, S. H., Wu, J., Zang, W. F., Dhingra, S., Sun, L., Weisel, R. D., Li, R-K. (2013). Interleukin-6 downregulation with mesenchymal stem cell differentiation results in loss of immunoprivilege. Journal of Cellular and Molecular Medicine, 17(9), 1136-45.

Yu, B. F., Wu, J., Zhang, Y., Sung, H. W., Xie, J., Li, R-K. (2013). Ultrasound-targeted HSVtk and Timp3 gene delivery for synergistically enhanced antitumor effects in hepatoma. Cancer Gene Therapy, 20(5), 290-7.

El-Mounayri, O., Mihic, A., Shikatani, E. A., Gagliardi, M., Steinbach, S. K., Dubois, N., Dacosta, R., Li, R-K, Keller, G., Husain, M. (2013). Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells. Circulation Research, 98(1), 125-35.

Li, S-H., Sun, Z., Brunt, K. R., Shi, X., Chen, M-S., Weisel, R. D., Li R-K. (2013). Reconstitution of aged bone marrow with young cells repopulates cardiac-resident bone marrow derived progenitor cells and prevents cardiac dysfunction after a myocardial infarction. European Heart Journal, 34(15), 1157-67.

Wu, S., Shang, H., Cui, L., Zhang, Z., Zhang, Y., Li, Y., Wu, J., Li, R-K., Xie, J. (2013). Targeted blockade of interleukin-8 abrogates its promotion of cervical cancer growth and metastasis. Molecular and Cellular Biochemistry, 375(1-2), 69-79.

Sun, L., Huang, C. W., Wu, J., Chen, K. J., Li, S-H., Weisel, R. D., Rakowski, H., Sung, H. W., Li, R-K. (2013). The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium. Biomaterials, 34(8), 2107-16.

Chen, Y., Yu, B., Xue, G., Zhao, J., Li, R-K., Liu, Z., Niu, B. (2013). Effects of storage solutions on the viability of human umbilical cord mesenchymal stem cells for transplantation. Cell Transplantation, 22(6), 1075-86.

Noyan-Ashraf, M. H., Shikatani, E. A., Schuiki, I., Mukovozov, I., Wu, J., Li, R-K., Volchuk, A., Robinson, L. A., Billia, F., Drucker, D. J., Husain, M. (2013). A glucagon-like peptide-1 analogue reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation, 127(1), 74-85.

Hsiao, C-W., Bai, M-Y., Chang, Y., Chung, M-F., Lee, T. Y., Wu, C-T., Maiti, B., Liao, Z-X., Li, R-K., Sung, H-W. (2013). Electrical coupling of isolated cardiomyocyte clusters grown on aligned conductive nanofibrous meshes for their synchronized beating. Biomaterials, 34(4), 1063-72.

Brunt, K. R., Weisel, R. D., & Li, R.-K. (2012). Stem cells and regenerative medicine - future perspectives. Canadian Journal of Physiology and Pharmacology, 90(3), 327–335.

Brunt, K. R., Zhang, Y., Mihic, A., Li, M., Li, S.-H., Xue, P., … Li, R.-K. (2012). Role of WNT/β-catenin signaling in rejuvenating myogenic differentiation of aged mesenchymal stem cells from cardiac patients. The American Journal of Pathology, 181(6), 2067–2078.

Di Nardo, P., Singla, D., & Li, R.-K. (2012). The challenges of stem cell therapy. Canadian Journal of Physiology and Pharmacology, 90(3), 273–274.

Sun, Z., Lee, C.-J., Mejia-Guerrero, S., Zhang, Y., Higuchi, K., Li, R.-K., & Medin, J. A. (2012). Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia. Human Gene Therapy, 23(12), 1280–1289.

Xaymardan, M., Sun, Z., Hatta, K., Tsukashita, M., Konecny, F., Weisel, R. D., & Li, R.-K. (2012). Uterine cells are recruited to the infarcted heart and improve cardiac outcomes in female rats. Journal of Molecular and Cellular Cardiology, 52(6), 1265–1273.

Yao, J., Jiang, S.-L., Liu, W., Liu, C., Chen, W., Sun, L., … Tian, H. (2012). Tissue inhibitor of matrix metalloproteinase-3 or vascular endothelial growth factor transfection of aged human mesenchymal stem cells enhances cell therapy after myocardial infarction. Rejuvenation Research, 15(5), 495–506.

Brunt, K. R., Wu, J., Chen, Z., Poeckel, D., Dercho, R. A., Melo, L. G., … Li, R.-K. (2012). Ex vivo Akt/HO-1 gene therapy to human endothelial progenitor cells enhances myocardial infarction recovery. Cell Transplantation, 21(7), 1443–1461.

Degousee, N., Simpson, J., Fazel, S., Scholich, K., Angoulvant, D., Angioni, C., … Rubin, B. B. (2012). Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction. Circulation, 125(23), 2904–2913.

Eguchi, M., Xu, G., Li, R.-K., & Sweeney, G. (2012). Diabetes influences cardiac extracellular matrix remodelling after myocardial infarction and subsequent development of cardiac dysfunction. Journal of Cellular and Molecular Medicine, 16(12), 2925–2934.

Hatta, K., Huang, M.-L., Weisel, R. D., & Li, R.-K. (2012). Culture of rat endometrial telocytes. Journal of Cellular and Molecular Medicine, 16(7), 1392–1396.

Kang, K., Sun, L., Xiao, Y., Li, S.-H., Wu, J., Guo, J., … Li, R.-K. (2012). Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration. Journal of the American College of Cardiology, 60(21), 2237–2249.

Li, S.-H., Sun, Z., Guo, L., Han, M., Wood, M. F. G., Ghosh, N., … Li, R.-K. (2012). Elastin overexpression by cell-based gene therapy preserves matrix and prevents cardiac dilation. Journal of Cellular and Molecular Medicine, 16(10), 2429–2439.

Tian, H., Huang, M.-L., Liu, K.-Y., Jia, Z.-B., Sun, L., Jiang, S.-L., … Li, R.-K. (2012). Inhibiting matrix metalloproteinase by cell-based timp-3 gene transfer effectively treats acute and chronic ischemic cardiomyopathy. Cell Transplantation, 21(5), 1039–1053.

Yang, W.-J., Li, S.-H., Weisel, R. D., Liu, S.-M., & Li, R.-K. (2012). Cell fusion contributes to the rescue of apoptotic cardiomyocytes by bone marrow cells. Journal of Cellular and Molecular Medicine, 16(12), 3085–3095.

Fujii, H., Li, S.-H., Wu, J., Miyagi, Y., Yau, T. M., Rakowski, H., … Li, R.-K. (2011). Repeated and targeted transfer of angiogenic plasmids into the infarcted rat heart via ultrasound targeted microbubble destruction enhances cardiac repair. European Heart Journal, 32(16), 2075–2084.

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